"Bringing A Truly Accurate Blood Test for Alzheimer’s Disease to the Market"

Over the past several years, researchers have come to believe that the best chance to prevent or slow the progression of Alzheimer’s disease (AD) is to begin treatment when patients are in the earliest stages of the disease, which is known to start many years before the onset of cognitive symptoms. A critical issue for researchers focused on developing treatments that could be initiated during the long pre-symptomatic phase of AD is reliable early detection. Current diagnostic methods for detection of AD are expensive and intrusive, with limited ability to identify asymptomatic individuals. There is a strong demand for a quick, easy and cost effective assay for the early detection of AD.

NanoSomiX , a molecular diagnostics laboratory, has developed a breakthrough technology capable of measuring the most critical known AD biomarkers in blood. Measurement of these biomarkers opens the door to early detection of AD as well as the potential for real time monitoring of the disease. The Company’s proprietary approach measures these key biomarkers by identifying, enriching and analyzing neural derived exosomes from blood. Exosomes are tiny membrane-encased vesicles which contain biomarkers known to be important in measuring neurologic status. Our first assay, NSX Direct™, uses neural derived exosomes to detect elevated levels of two key proteins involved in the pathogenesis of AD (p-tau and Abeta). These markers are well known to correlate with disease and have been shown to increase up to ten years before the onset of cognitive impairment. Our technology is the only approach that can measure both biomarkers in blood, giving our assay the potential to be the most practical and cost effective AD diagnostic methodology available.

NanoSomiX is now offering NSX Direct™ for Research Use Only (RUO) with plans to transition to a Laboratory Developed Test (LDT) with additional validation studies. Our assays are performed in a federally regulated clinical (CLIA) laboratory. In the near future, we will be introducing new assay panels that include additional AD-related biomarkers. Moving forward, we plan to expand our technology platform to include a vast array of biomarkers focused on neurodegenerative, neuroinflammatory and neurotraumatic diseases.

News and Events

6/16/2015 – Specialized Proteins May Be Detected in Blood of People with Alzheimer's Disease

Specialized brain proteins that are involved in the removal of damaged nerve cell materials may be detected in the blood of people who were diagnosed with mild cognitive impairment or dementia due to Alzheimer’s disease. In a select group of people who later developed dementia, the levels of the lysosomal proteins were abnormal while the people still had no problems with memory or thinking skills, according to a study published in the June 10, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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11/17/2014 - Research on Blood Test for Brain Insulin Resistance Is Featured at Society for Neuroscience Conference

A new blood test that detects brain insulin resistance, as an abnormality associated with Alzheimer’s disease, was featured by meeting organizers as a “Hot Topic” presentation at the recent annual meeting of the Society for Neuroscience (SFN). The conference, held here in Washington Nov. 15-19, is the world’s largest meeting on brain science.

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10/30/2014 - Study Says Blood Test for Brain Insulin Resistance Accurately Predicts Alzheimer's Disease Risk

Brain insulin resistance is an abnormality in Alzheimer’s disease that contributes to neural cell damage and can be detected by a new blood test, according to a multi-site study that was published October 23 in the online issue of The FASEB Journal, The Journal of the Federation of American Societies for Experimental Biology. The highly statistically significant findings were made possible by a novel technique the researchers developed for measuring brain insulin resistance in living patients.

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